A computational tool supporting the use of NGRA workflows
NAMASTOX is an online software with a web-based graphical interface, developed for supporting the application of the ASPA workflow in practice.
The ASPA workflow, developed by the ASPIS cluster, is the interactive NGRA (New Generation Risk Assessment) workflow that guides users through all steps and decisions of the risk assessment process.
In this context, NAMASTOX was developed by one of the ASPIS cluster projects (RISK-HUNT3R) specifically aiming to support the ASPA workflow and facilitate its application.
NAMASTOX is open source, accesible here, and can be installed in a private server, or locally on a desktop computer, allowing its application to sensitive data.
It works in most operative systems and environments, from an AWS cloud environment to a Windows laptop. Moreover, risk assessments conducted with NAMASTOX can be easily exported and shared.
Features
1. Guidance
NAMASTOX allows navigating the workflow step-by-step.
The interface shows a simplified view of the workflow including only the visited nodes and the next tasks or decisions, organized in blocks.
2. Results
NAMs results can be entered in different formats and levels of detail, attaching also files. Decisions are documented to improve the ASPA workflow transparency and reproducibility.
NAM results can be consulted from a centralized repository.
3. Running In silico tools
In silico tools (e.g., models for predicting hazard or ADME properties) can be run directly from NAMASTOX. The results are automatically collected.
QSAR Models developed in Flame can be imported directly from the interface.
4. Reporting
At any point of the assessment NAMASTOX can generate a report in standard formats like Word or Excel, presenting all the results in a clear and organized way.
This report contains live links to attached files and documents.
5. Uncertainty management
The uncertainty of NAM results can be incorporated using the methods’ reliability or actual probabilities (when available).
Decisions in the ASPA workflow are supported by presenting previous NAM results and associated uncertainties.
Documentation
An introductory video is available here.
We prepared a series of short (1 to 2 minutes) videos explaining how to carry out common tasks:
- create a new RA here
- executing a task here
- making decisions here
- review results and decisions here
- generating reports here
- project management here
Here is also the link to a quickstarting guide: here
Acknowledgments
NAMASTOX has been developed for the project RISKHUNT3R (https://www.risk-hunt3r.eu/)
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 964537.