The Biopsycho project was a coordinated research project aimed to the development of novel strategies for the discovery of antipsychotic drugs. This project was the last edition of a long term collaboration between the departments of Pharmacology and Medicinal Chemistry of the University of Santiago de Compostela and the GRIB at University Pompeu Fabra.
This last edition of the project was funded in 2005 by the Spanish Ministerio de Educacion y Ciencia (SAF2005-08025) as a coordinated project involving three diferent subprojects:
- Subproject of Pharmacology
Santiago de Compostela University, Pharmacy Faculty
María Isabel Loza García (coordinadora) - Subproject of Medicinal Chemistry
Santiago de Compostela University, Pharmacy Faculty
Jorge Christian Fernández Masaguer - Subproject of Biocomputation
Pompeu Fabra University, Research Unit on Biomedical Informatics
Manuel Pastor Maeso
The objectives of the project were:
- Define Multireceptoral Pharmacological Profiles (PFM) associated to therapeutic effects of antipsychotics.
- Define Conformational Pharmacological Profiles (PCM) through the analysis of the conformational expression of the GPCRs involved in psychosis.
- Build and validate mathematical models of the relation structure/PFM/PFC.
- Design and synthesize compounds with optimum pharmacological profiles.